Rheumatoid factor neutralizing buffer

Rheumatoid factors (RFs) are a critical issue in immunoassays, where RFs present in serum from patients with rheumatoid arthritis and related connective tissue diseases often cause false positive results by bridging capture and detection antibodies. This phenomenon, leading to non-specific signals may similarly result in signals higher than expected when measuring IgA and IgM, and is usually referred to as RF enhancement. The RF neutralizing buffer is a RF interfering buffer, which neutralizes RF and heterophilic antibody interference and ultimately false positive results and RF enhancement